weddnesdday-addams:
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HAVE PEOPLE NOT HEARD OF LIBRARIES??????? They are 100% cheaper than AMAZON

Certified Oh My God Please Use Libraries If You Can Post

I beg of you, use the damn library instead. You can still order them from Amazon after you've browsed, if you must (why tho?), but if you leave the books you've browsed out to be reshelved, you are also helping the library with their usage counts! And you won't have been a giant asshole to poor retail workers.

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the singular most best thing to come out of the Nora renaissance for ME mattandneil alive and THRIVING in 2023

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the singular most best thing to come out of the Nora renaissance for ME mattandneil alive and THRIVING in 2023

NORA CALLED NEIL MATT'S LITTLE BROTHER, I'M CRYING AND THROWING UP

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modern social media should stop offering "sync with your phone contacts to follow them" options and start offering "block all your phone contacts so they never see your account" options

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hbd to tumblr’s pride and joy

Demonstrating some wushu skills

[eng by me]

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why is this about to make me sob

a poem i am sure everyone has seen but i'm still going to share anyway

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as well as this other poem inspired by giovanni's

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and this beautiful tweet

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Panel 1: Pulling out we finally see more of the wall which has the door to the screen porch. Directly beside it is a cat door that goes through the wall, out into the screen porch. Another cat, Bunny’s sister Maggie, is coming through the cat flap with no issue.   I say, “ Bunny, I know you know how to use the cat door.”  Clawing at the window, tears in her eyes, Bunny screams “MAMA!!”ALT

Image description: A four page black and white comic of my tortoiseshell cat, Bunny, complaining that I won’t let her in from the screen porch.

Page 1 

Panel 1: A small tortoiseshell cat sits on the other side of a glass door, looking up sadly, saying, “Mama! Mama, help! I’m in the screen porch!” 

Panel 2: She scratches at the door. “Mama! Mama I’m trapped! I’m trapped in the screen porch! Mama!” she cries. 

Panel 3: She looks through the glass with her sad, innocent expression. “I see you, Mama! Can’t you hear me? Why won’t you let me in? What have I done, Mama!”

Panel 4: The left corner is dominated by a close up of her face, as she reminisces about the cat tree in the screen porch. We see her perched on the very top, looking out over the backyard.

She says, “Was I not grateful enough, Mama? You gave me a throne, here in the screen porch! A place where I could look down upon the world as a god!”

Page 2

Panel 1: While she’s perched atop her cat tree, it begins to rain outside. Bunny looks askance at it from behind the screen. 

“But I couldn’t touch it, Mama!” she narrates, now in boxes instead of word balloons, “I could see the rain lavish the earth, but never feel its cool caress!”

Panel 2: A paw rests on the screen. On the other side, two birds chirp, unbothered by the presence of Bunny.

 “I could smell the blood of the song birds, but never taste its warmth! I lived as Tantalus in this screen porch, Mama!”

Panel 3: Sitting on a cushioned chair, bunny looks out over the yard, barred from her by the porch screen. 

“Tormented by what I could never reach!” 

Page 3

Panel 1 : Another reminiscence, this time of Bunny running through the open door to the screen porch earlier that day while I was taking out the garbage. 

“And yet I returned, again and again and again! Was that my sin, Mama? Is this my punishment? To be condemned forever to a hell of my own choosing?” 

Panel 2: Returning to the present, Bunny looks up from the otherside of the door, her eyes wide.

“Is this what you call justice, Mama?” She says. “Is this what you call love?” 

Panel 3: From Bunny’s perspective we see me; I am ignoring her, going about my business. She calls out to me, “Answer me, Mama! Mama!”

Panel 4:I glance back at her, unmoved by her cries. “Mama!” she yells. 

Page 4

Panel 1: Pulling out we finally see more of the wall which has the door to the screen porch. Directly beside it is a cat door that goes through the wall, out into the screen porch. Another cat, Bunny’s sister Maggie, is coming through the cat flap with no issue.

 I say, “ Bunny, I know you know how to use the cat door.”

Clawing at the window, tears in her eyes, Bunny screams “MAMA!!”

End ID.

I feel like “is this what you call justice, Mama? is this what you call love?” is going to enter my “cats being dramatic” lexicon the same way “you KICK miette?” and “father is…evil?” have.

so my fridge is covered in femboy pinups i got when i was a subscriber to this porn artist's patreon and i just have like so many femboy pinups and also a furry pinup on my fridge it really is quite erotic

and my wifi password is "onthefridge"

so whenever someone new comes over and i offer to let them use the wifi i tell them the password is "onthefridge" and they go and look at the fridge and are met with all this femboy ass and are like where is it there's a lot of stuff here and i reiterate it's onthefridge and they go where!!! and i come over and type "onthefridge" into their phone and they get so mad

Is this a prank? What….

Edit: holy heck it’s real…

They might be able to help us…

The stage that they're at is animal testing but it sounds like it's been successful in mouse and primate models.

My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.

The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.

There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.

*theres like a lot medical science doesnt know about the immune system

Thank you for this explanation/synthesis of the article! It's important for us to understand that they're still in early development and testing of these methods, but also that they've seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.

Hi! I'm a microbiologist and I've done work in academia, pharma, and clinical trials.

So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).

The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.

The phase 1 MS trial is currently active, estimated completion in summer 2024.

I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.

Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It's way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.

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